Intraocular Dissemination of Uveal Melanoma Cells Following Radiotherapy: Evolving Management Over the Past Decade

Cutaneous halo nevi following plaque radiotherapy for uveal melanoma.

performed. Previous cases of vitelliform retinopathy have had some clinical findings consistent with MAR, while others have not. None of these reports had clinical evidence of choroidal involvement. The vitelliform lesions have been postulated to represent a new paraneoplastic clinical manifestation. The pathologic results in this case argue against a paraneoplastic entity but may suggest a loc...

Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma.

OBJECTIVE To identify the risk factors that lead to the development of radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Radiation retinopathy is a slowly progressive, occlusive vasculopathy characterized by radiation-induced endothelial damage. METHODS Review of the medical records of patients with posterior uveal melanoma treated with plaque radiotherapy. R...

Cutaneous vitiligo following management of uveal melanoma in 6 patients.

IMPORTANCE The relationship of vitiligo to cutaneous melanoma is believed to be due to an immune response generated to melanoma antigens that cross-react with normal skin. There is little in the literature on the relationship between cutaneous vitiligo and uveal melanoma. OBJECTIVE To describe the clinical profile, treatment, and outcome in patients with uveal melanoma who subsequently develo...

Uveal melanoma management.

Surveillance options for patients with uveal melanoma following definitive management.

Even though less than 1% of uveal melanoma patients are found to have radiographic or clinical evidence of distant disease at the time of treatment for their intraocular disease, they carry a lifetime risk of disease recurrence, with approximately 50% of patients ultimately developing fatal metastases. Despite this significant risk, there is no consensus within the ophthalmologic or oncologic c...